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ea0016p176 | Diabetes and cardiovascular diseases | ECE2008

Adiponectin stimulates monocytic release of CCL2, -3, -4 and -5 concomitantly reduces the surface abundance of CCR1, -2 and -5

Weigert Johanna , Neumeier Markus , Bruhl Hilke , Bollheimer Cornelius , Buttner Roland , Schaffler Andreas , Scholmerich Jurgen , Buechler Christa

Background: Systemic adiponectin is reduced in patients with obesity and type 2 diabetes mellitus. Peripheral monocytes of type 2 diabetic patients are activated and show a higher surface abundance of CCR2. Inflammatory markers like CCL2 are elevated in the serum of these patients. Therefore, the influence of adiponectin on the release of CC chemokines and the abundance of the corresponding receptors were investigated in monocytic cells.Methods: Primary ...

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Endocrine Abstracts

Adiponectin stimulates monocytic release of CCL2, -3, -4 and -5 concomitantly reduces the surface abundance of CCR1, -2 and -5

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